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Literature summary extracted from

  • Cerf, M.E.; Raidoo, D.M.
    Immunolocalization of plasma kallikrein in human brain (2000), Metab. Brain Dis., 15, 315-323.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.34 additional information activation of prekallikrein to active kallikrein proceeds via hydrolysis of the bond Arg371-Ile372 leading to formation of 2 chains connected via 2 disulfide bonds Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.34 cytosol ependymal cells Homo sapiens 5829
-
3.4.21.34 soluble prekallikrein, plasma Homo sapiens
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.21.34 33000
-
 x * 88000, prekallikrein, SDS-PAGE, x * 33000, kallikrein light chain, SDS-PAGE, x * 55000, kallikrein heavy chain, SDS-PAGE Homo sapiens
3.4.21.34 55000
-
 x * 88000, prekallikrein, SDS-PAGE, x * 33000, kallikrein light chain, SDS-PAGE, x * 55000, kallikrein heavy chain, SDS-PAGE Homo sapiens
3.4.21.34 88000
-
 x * 88000, prekallikrein, SDS-PAGE, x * 33000, kallikrein light chain, SDS-PAGE, x * 55000, kallikrein heavy chain, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.34 kininogen + H2O Homo sapiens enzyme is a cofactor in blood coagulation and modulates inflammation through release of bradykinin bradykinin + fragment of kininogen
-
 ir

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.34 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.34 adrenal gland prekallikrein expression Homo sapiens
-
3.4.21.34 blood prekallikrein expression Homo sapiens
-
3.4.21.34 brain prekallikrein expression Homo sapiens
-
3.4.21.34 brain stem prekallikrein expression Homo sapiens
-
3.4.21.34 cerebral cortex prekallikrein expression Homo sapiens
-
3.4.21.34 endothelium prekallikrein expression Homo sapiens
-
3.4.21.34 ependymal cell in sections of hypothalamus and spinalcord, prekallikrein expression Homo sapiens
-
3.4.21.34 epithelial cell prekallikrein expression Homo sapiens
-
3.4.21.34 fibre tract of pons, hipocampus, and medulla, prekallikrein expression Homo sapiens
-
3.4.21.34 fibroblast prekallikrein expression Homo sapiens
-
3.4.21.34 heart prekallikrein expression Homo sapiens
-
3.4.21.34 hepatocyte prekallikrein Homo sapiens
-
3.4.21.34 hippocampus some fibre tracts, prekallikrein expression Homo sapiens
-
3.4.21.34 hypothalamus prekallikrein expression Homo sapiens
-
3.4.21.34 kidney prekallikrein expression Homo sapiens
-
3.4.21.34 leukocyte prekellikrein expression Homo sapiens
-
3.4.21.34 liver prekallikrein, secretion into blood circulation Homo sapiens
-
3.4.21.34 lung prekallikrein expression Homo sapiens
-
3.4.21.34 medulla oblongata some fibre tracts, prekallikrein expression Homo sapiens
-
3.4.21.34 midbrain prekallikrein expression Homo sapiens
-
3.4.21.34 additional information no expression of prekallikrein in the choroid plexus or the cerebellum Homo sapiens
-
3.4.21.34 neuron prekallikrein expression Homo sapiens
-
3.4.21.34 pancreas
-
 Homo sapiens
-
3.4.21.34 pituitary gland secretory cells, prekallikrein expression Homo sapiens
-
3.4.21.34 placenta prekallikrein expression Homo sapiens
-
3.4.21.34 plasma prekallikrein expression Homo sapiens
-
3.4.21.34 pons some fibre tracts, prekallikrein expression Homo sapiens
-
3.4.21.34 spinal cord prekallikrein expression Homo sapiens
-
3.4.21.34 thalamus prekallikrein expression Homo sapiens
-
3.4.21.34 trachea prekallikrein expression Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.21.34 additional information
-
 activity in pancreas and brain Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.34 kininogen + H2O
-
 Homo sapiens bradykinin + fragment of kininogen
-
 ?
3.4.21.34 kininogen + H2O enzyme is a cofactor in blood coagulation and modulates inflammation through release of bradykinin Homo sapiens bradykinin + fragment of kininogen
-
 ir

Subunits

EC Number Subunits Comment Organism
3.4.21.34 ? x * 88000, prekallikrein, SDS-PAGE, x * 33000, kallikrein light chain, SDS-PAGE, x * 55000, kallikrein heavy chain, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.4.21.34 PK
-
 Homo sapiens
3.4.21.34 PPK i.e. plasma prekallikrein Homo sapiens